Gnetum montanum Markgr. belongs to the Gnetaceae family. According to traditional medicine, this species has the effect of preventing leprosy, eliminating rheumatism, activating blood, and eliminating inflammation, and has been used in remedies for rheumatism, bone pain, and gout treatment. In Vietnam, there are various commercial products to treat arthritis and gout. With the goal of isolating compounds from this species in Vietnam, in the continous phytochemical investigation of stem of Gnetum montanum Markgr, we used extraction methods with increasing polar solvents and modern chromatography methods such as thin-layer chromatography. (TLC), column chromatography (CC), high-performance liquid chromatography (HPLC). As a result, 4 compounds were first time isolated from the G. montanum stem. They were two dimeric stilbenes gneafricanin F (1), gnetuhainin Q (2) together with one stilbene 2,3′,5′-trihydoxy-trans-stilbene (3), homoeriodictynol (4). Their structures were determined by ESI-MS, 1D-NMR, and 2D-NMR combined with comparison with published spectral data.
Keyword
Gnetum montanum Markgr., stilbenoids, extraction and isolation, structure.
Authors : Truong Hoai Nam, Doan Thi Hoa Huyen, Nguyen Thi Thu Hang, Nguyen Vo Hong Ngoc, Tran Huy Trong, Do Kim Thanh, Nguyen Huu Tuan Minh, Tran Thi Luyen, Tran Quang Tung, Tran Thi Thuy*, Vu Quynh Nhu